This study led by our colleague Dr Michael Eyre from King’s College, London, looked at individual patient data across the world and across time, finding 1479 patients.

Those receiving at least 1 month of corticosteroids had a median chorea duration of 1.2 months vs 2.8 months for patients receiving none, a significant difference.

Patients treated with antibiotics, corticosteroids, or sodium valproate had significantly reduced odds of relapse.

Conclusion – These observational data support the use of corticosteroids, antibiotics, and sodium valproate for treatment of Sydenham chorea.

[JAMA Netw Open. 2024;7(4):e246792] 

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